Article
Mendelian randomization: using genes as instruments for making causal inferences in epidemiology.
Statistics in medicine - 15 Apr 2008
Lawlor Debbie A, Harbord Roger M, Sterne Jonathan A C, Timpson Nic, Davey Smith George
Abstract excerpt
Observational epidemiological studies suffer from many potential biases, from confounding and from reverse causation, and this limits their ability to robustly identify causal associations. Several high-profile situations exist in which randomized controlled trials of precisely the same intervention that has been examined in observational studies have produced markedly different findings. In other observational...
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