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Article

Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.

Disease models & mechanisms - 1 Oct 2014

Jackrel Meredith E, Shorter James

Abstract excerpt

Protein misfolding is implicated in numerous lethal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD). There are no therapies that reverse these protein-misfolding events. We aim to apply Hsp104, a hexameric AAA+ protein from yeast, to target misfolded conformers for reactivation. Hsp104 solubilizes disordered aggregates and amyloid, but has limited activity...

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Source

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Identifiers

PMID: 25062688
DOI: 10.1242/dmm.016113
PMCID: PMC4174528

Genes

EWSR1
FUS
TAF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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