Article

Overexpression of DnaJ chaperones in ameliorating toxicities associated with FUS and TDP-43

2025-06-01

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is an adult-onset neurodegenerative disease. It primarily affects the motor neurons, leading to muscle weakness and eventually death of the patients. Various factors, such as genetics, environment, age, etc, are involved in the etiopathogenesis of ALS. As ALS is a highly challenging and complex disease involving various pathogeneses linked with progressive motor neuron degenerat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5b1e831-4f1c-5f1d-af66-b15bb81d1da8
DOI: 10.1101/2025.05.28.656528

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Overexpression of DnaJ chaperones in ameliorating toxicities associated with FUS and TDP-43DOI 10.1101/2025.05.28.656528Read

Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington’s DiseaseSemantic proximity Read

Identification of two novel DnaJ chaperone family proteins as modifiers of Huntingtin aggregatesSemantic proximity Read

Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral SclerosisSemantic proximity Read

Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathologySemantic proximity Read

A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and gliaSemantic proximity Read

A multiplex platform to identify mechanisms and modulators of proteotoxicity in neurodegenerationSemantic proximity Read

Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcomaSemantic proximity Read

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicitySemantic proximity Read

A Genetic Screen for Human Genes Suppressing FUS Induced Toxicity in Yeast.Semantic proximity Read

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.Semantic proximity Read

A yeast model of FUS/TLS-dependent cytotoxicity.Semantic proximity Read

RNA-binding proteins with prion-like domains in ALS and FTLD-USemantic proximity Read