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Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma

6 Jun 2019

Abstract excerpt

genes are also prone to chromosomal translocation events, which result in aberrant fusions between portions of the PrLDs of FUS and EWSR1 and the transcription factors CHOP and FLI. The resulting fusion proteins, FUS-CHOP and EWS-FLI, drive aberrant transcriptional programs that underpin liposarcoma and Ewing's sarcoma, respectively. The translocated PrLDs alter the expression profiles of these proteins and...

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PMID: 31171724
DOI: 10.1074/jbc.ra119.009494

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