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Article

Structure and function of the molecular chaperone Hsp104 from yeast.

Biopolymers - 1 Mar 2010

Grimminger-Marquardt Valerie, Lashuel Hilal A

Abstract excerpt

The molecular chaperone Hsp104 plays a central role in the clearance of aggregates after heat shock and the propagation of yeast prions. Hsp104's disaggregation activity and prion propagation have been linked to its ability to resolubilize or remodel protein aggregates. However, Hsp104 has also the capacity to catalyze protein aggregation of some substrates at specific conditions. Hence, it is a molecular...

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PMID: 19768774
DOI: 10.1002/bip.21301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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