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Article

Therapeutic genetic variation revealed in diverse Hsp104 homologs.

eLife - 15 Dec 2020

March Zachary M, Sweeney Katelyn, Kim Hanna, Yan Xiaohui, Castellano Laura M, Jackrel Meredith E, Lin JiaBei, Chuang Edward, Gomes Edward, Willicott Corey W, Michalska Karolina, Jedrzejczak Robert P, Joachimiak Andrzej, Caldwell Kim A, Caldwell Guy A, Shalem Ophir, Shorter James

Abstract excerpt

The AAA+ protein disaggregase, Hsp104, increases fitness under stress by reversing stress-induced protein aggregation. Natural Hsp104 variants might exist with enhanced, selective activity against neurodegenerative disease substrates. However, natural Hsp104 variation remains largely unexplored. Here, we screened a cross-kingdom collection of Hsp104 homologs in yeast proteotoxicity models. Prokaryotic ClpG...

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Identifiers

PMID: 33319748
DOI: 10.7554/eLife.57457
PMCID: PMC7785292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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