Article

Design principles to tailor Hsp104 therapeutics

2024-04-28

Abstract excerpt

The hexameric AAA+ disaggregase, Hsp104, collaborates with Hsp70 and Hsp40 via its autoregulatory middle domain (MD) to solubilize aggregated protein conformers. However, how ATP- or ADP-specific MD configurations regulate Hsp104 hexamers remains poorly understood. Here, we define an ATP-specific network of interprotomer contacts between nucleotide-binding domain 1 (NBD1) and MD helix L1, which tunes Hsp70 collabo...

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Literature Corpus work: 246c2e17-e66c-5730-8e20-ad1c870f8f32
DOI: 10.1101/2024.04.26.591398

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