Article
Ssd1 is required for thermotolerance and Hsp104-mediated protein disaggregation in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Jan 2009
Mir Snober S, Fiedler David, Cashikar Anil G
Abstract excerpt
In the budding yeast Saccharomyces cerevisiae, the Hsp104-mediated disaggregation of protein aggregates is essential for thermotolerance and to facilitate the maintenance of prions. In humans, protein aggregation is associated with neuronal death and dysfunction in many neurodegenerative diseases. Mechanisms of aggregation surveillance that regulate protein disaggregation are likely to play a major role in cell...
Topics
- Adaptation, Physiological
- Genes, Essential
- Genome, Fungal
- Heat-Shock Proteins
- Heat-Shock Response
- Mutant Proteins
- Mutation
- Protein Structure, Quaternary
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins