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Article

Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jun 2017

Kaimal Jayasankar Mohanakrishnan, Kandasamy Ganapathi, Gasser Fabian, Andréasson Claes

Abstract excerpt

Protein aggregation is intimately associated with cellular stress and is accelerated during aging, disease, and cellular dysfunction. Yeast cells rely on the ATP-consuming chaperone Hsp104 to disaggregate proteins together with Hsp70. Hsp110s are ancient and abundant chaperones that form complexes with Hsp70. Here we provide in vivo data showing that the Saccharomyces cerevisiae Hsp110s Sse1 and Sse2 are...

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Identifiers

PMID: 28289075
DOI: 10.1128/MCB.00027-17
PMCID: PMC5440654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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