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Article

Mechanism of actin filament pointed-end capping by tropomodulin.

Science (New York, N.Y.) - 25 Jul 2014

Rao Jampani Nageswara, Madasu Yadaiah, Dominguez Roberto

Abstract excerpt

Proteins that cap the ends of the actin filament are essential regulators of cytoskeleton dynamics. Whereas several proteins cap the rapidly growing barbed end, tropomodulin (Tmod) is the only protein known to cap the slowly growing pointed end. The lack of structural information severely limits our understanding of Tmod's capping mechanism. We describe crystal structures of actin complexes with the unstructured...

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Identifiers

PMID: 25061212
DOI: 10.1126/science.1256159
PMCID: PMC4367809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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