Article
Phosphorylation of tropomodulin1 contributes to the regulation of actin filament architecture in cardiac muscle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2014
Bliss Katherine T, Tsukada Takehiro, Novak Stefanie Mares, Dorovkov Maxim V, Shah Samar P, Nworu Chinedu, Kostyukova Alla S, Gregorio Carol C
Abstract excerpt
Tropomodulin1 (Tmod1) is an actin-capping protein that plays an important role in actin filament pointed-end dynamics and length in striated muscle. No mechanisms have been identified to explain how Tmod1's functional properties are regulated. The purpose of this investigation was to explore the functional significance of the phosphorylation of Tmod1 at previously identified Thr54. Rat cardiomyocytes were...
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