Article

<i>Drosophila</i> Tropomodulin is required for multiple actin-dependent processes in myofiber assembly and maintenance

2022-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Proper muscle contraction requires the assembly and maintenance of sarcomeres and myofibrils. While the protein components of myofibrils are generally known, less is known about the mechanisms by which they individually function and together synergize for myofibril assembly and maintenance. For example, it is unclear how the disruption of actin filament (F-actin) regulatory proteins leads to the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d0c47f4-26d7-532f-aa50-73a44c19e5ff
DOI: 10.1101/2022.08.05.502981

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Drosophila</i> Tropomodulin is required for multiple actin-dependent processes in myofiber assembly and maintenanceDOI 10.1101/2022.08.05.502981Read

Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.Semantic proximity Read

Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality.Semantic proximity Read

Rewiring Fibroblast–Muscle Axis Drives Progressive Pathology in Bethlem MyopathySemantic proximity Read

Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy.Semantic proximity Read

Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegans.Semantic proximity Read

Bruno 1 regulates cytoskeleton dynamics and a temporal splicing transition to promote myofibril assembly, growth and maturation in <i>Drosophila</i> flight muscleSemantic proximity Read

Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy.Semantic proximity Read

Cofilin loss in <i>Drosophila</i> contributes to myopathy through defective sarcomerogenesis and aggregate formation during muscle growthSemantic proximity Read

KLHL41 orchestrates sarcomere assembly and size to drive skeletal muscle hypertrophy <i>in vivo</i>Semantic proximity Read

Bruno 1/CELF regulates splicing and cytoskeleton dynamics to ensure correct sarcomere assembly in Drosophila flight musclesSemantic proximity Read

Alteration of tropomyosin-binding properties of tropomodulin-1 affects its capping ability and localization in skeletal myocytes.Semantic proximity Read

Emerging issues for tropomyosin structure, regulation, function and pathology.Semantic proximity Read