Article
Leiomodin 2 is a processive pointed-end elongator of actin filaments.
Nature communications - 20 Jul 2026
Biswas Sudipta, Larrinaga Tania M, Choubey Sandeep, Gregorio Carol C, Shekhar Shashank
Abstract excerpt
The actin cytoskeleton drives essential processes like cell migration and muscle contraction. While barbed-end polymerization is well-established, pointed-end elongation was long considered impossible in vivo. Here, we demonstrate that Leiomodin 2 (Lmod2), which localizes to thin-filament pointed ends in striated muscle cells, functions as an actin polymerase for pointed-end elongation. Single-molecule and...
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