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Article

Role of tropomodulin's leucine rich repeat domain in the formation of neurite-like processes.

Biochemistry - 29 Apr 2014

Guillaud Laurent, Gray Kevin T, Moroz Natalia, Pantazis Caroline, Pate Edward, Kostyukova Alla S

Abstract excerpt

Actin dynamics is fundamental for neurite development; monomer depolymerization from pointed ends is rate-limiting in actin treadmilling. Tropomodulins (Tmod) make up a family of actin pointed end-capping proteins. Of the four known isoforms, Tmod1-Tmod3 are expressed in brain cells. We investigated the role of Tmod's C-terminal (LRR) domain in the formation of neurite-like processes by overexpressing Tmod1 and...

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Identifiers

PMID: 24746171
DOI: 10.1021/bi401431k
PMCID: PMC4018078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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