Article

Leiomodin 2 functions as a processive pointed-end elongator of actin filaments

2026-05-07

Abstract excerpt

<h4>ABSTRACT</h4> The actin cytoskeleton drives essential processes like cell migration and muscle contraction. While barbed-end polymerization is well-established, pointed-end elongation was long considered impossible in vivo . Here, we demonstrate that Leiomodin 2 (Lmod2), which localizes to thin-filament pointed ends (PEs) in striated muscle cells, functions as the first identified eukaryotic processive actin...

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Literature Corpus work: 84c0369d-fd59-523a-89fe-471737297708
DOI: 10.64898/2026.05.04.720848

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