Article
Alteration of tropomyosin-binding properties of tropomodulin-1 affects its capping ability and localization in skeletal myocytes.
The Journal of biological chemistry - 15 Feb 2013
Moroz Natalia A, Novak Stefanie M, Azevedo Ricardo, Colpan Mert, Uversky Vladimir N, Gregorio Carol C, Kostyukova Alla S
Abstract excerpt
Tropomodulin (Tmod) is an actin-capping protein that binds to the two tropomyosins (TM) at the pointed end of the actin filament to prevent further actin polymerization and depolymerization. Therefore, understanding the role of Tmod is very important when studying actin filament dependent processes such as muscle contraction and intracellular transport. The capping ability of Tmod is highly influenced by TM and...
Topics
- Actin Cytoskeleton
- Actins
- Amino Acid Sequence
- Animals
- Binding Sites
- Chickens
- Circular Dichroism
- Gene Expression Regulation
- Mice
- Microscopy, Fluorescence
- Molecular Sequence Data
- Muscle Cells
- Muscle, Skeletal