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Article

Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3.

Cytoskeleton (Hoboken, N.J.) - 1 Jul 2014

Lewis Raymond A, Yamashiro Sawako, Gokhin David S, Fowler Velia M

Abstract excerpt

Tropomodulins (Tmods) interact with tropomyosins (TMs) via two TM-binding sites and cap the pointed ends of TM-coated actin filaments. To study the functional interplay between TM binding and TM-actin filament capping by Tmods, we introduced disabling mutations into the first, second, or both TM-binding sites of full-length Tmod1 (Tmod1-L27G, Tmod1-I131D, and Tmod1-L27G/I131D, respectively) and full-length Tmod3...

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Identifiers

PMID: 24922351
DOI: 10.1002/cm.21179
PMCID: PMC4347929

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