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Article

A Crucial Role for CDC42 in Senescence-Associated Inflammation and Atherosclerosis

24 Jul 2014

Abstract excerpt

Risk factors for atherosclerosis accelerate the senescence of vascular endothelial cells and promote atherogenesis by inducing vascular inflammation. A hallmark of endothelial senescence is the persistent up-regulation of pro-inflammatory genes. We identified CDC42 signaling as a mediator of chronic inflammation associated with endothelial senescence. Inhibition of CDC42 or NF-κB signaling attenuated the...

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Share to Atherosclerosis and Cardiovascular Diseases
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PMID: 25057989
DOI: 10.1371/journal.pone.0102186

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