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Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis

16 Jul 2021

Abstract excerpt

Senescent vascular cells are detected in atherosclerotic lesion, and its involvement in the development of atherosclerosis has been revealed; however, whether and the mechanism by which endothelial cell (EC) senescence is causally implicated in atherosclerosis remains unclear. We here investigate a role of EC senescence in atherosclerosis by utilizing EC-specific progeroid mice that overexpress the dominant...

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PMID: 34272458
DOI: 10.1038/s41598-021-94097-5

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