Endothelial cell telomere dysfunction induces senescence and results in vascular and metabolic impairments

Abstract excerpt

In advanced age, increases in oxidative stress and inflammation impair endothelial function, which contributes to the development of cardiovascular disease (CVD). One plausible source of this oxidative stress and inflammation is an increase in the abundance of senescent endothelial cells. Cellular senescence is a cell cycle arrest that occurs in response to various damaging stimuli. In the present study, we...

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• Share to Telomeres, Telomerase, and Senescence