Article
Notch activation induces endothelial cell senescence and pro-inflammatory response: implication of Notch signaling in atherosclerosis.
Atherosclerosis - 1 Dec 2012
Liu Zhao-Jun, Tan Yurong, Beecham Gary W, Seo David M, Tian Runxia, Li Yan, Vazquez-Padron Roberto I, Pericak-Vance Margaret, Vance Jeffery M, Goldschmidt-Clermont Pascal J, Livingstone Alan S, Velazquez Omaida C
Abstract excerpt
OBJECTIVE: Notch signaling plays pivotal roles in the pathogenesis of vascular disease. However, little is known about its role in atherosclerosis. We sought to investigate the potential involvement of the Notch signaling in atherosclerosis. METHODS: Expression of Notch pathway components in mouse and human aorta with or without atherosclerosis plaque was examined by immunohistochemistry. Expression of Notch...
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