Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel role for YPEL2 in mediating endothelial cellular senescence via the p53/p21 pathway

22 Mar 2023

Abstract excerpt

Yippee-like 2 (YPEL2) is expressed in tissues and organs enriched in vascular networks, such as heart, kidney, and lung. However, the roles of YPEL2 in endothelial cell senescence and the expression of YPEL2 in atherosclerotic plaques have not yet been investigated. Here, we report the essential role of YPEL2 in promoting senescence in human umbilical vein endothelial cells (HUVECs) and the upregulation of YPEL2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidant Activity and Oxidative Stress
Share to Corneal surgery and disorders

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36963468
DOI: 10.1016/j.mad.2023.111803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel role for YPEL2 in mediating endothelial cellular senescence via the p53/p21 pathwayPMID 36963468Read ↗

Alteration of E2F2 Expression in Governing Endothelial Cell SenescenceSemantic proximity Read ↗

Vascular cellular senescence in human atherosclerosis: The critical modulating roles of CDKN2A and CDK4/6 signaling pathwaysSemantic proximity Read ↗

Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseasesSemantic proximity Read ↗

YAP accelerates vascular senescence via blocking autophagic flux and activating mTORSemantic proximity Read ↗

UGP2, a novel target gene of TP53, inhibits endothelial cells apoptosis and atherosclerosisSemantic proximity Read ↗

H2O2 down-regulates SIRT7’s protective role of endothelial premature dysfunction via microRNA-335-5pSemantic proximity Read ↗

Cellular Senescence, Vascular Disease, and AgingSemantic proximity Read ↗

Histone methyltransferase Smyd3 is a new regulator for vascular senescenceSemantic proximity Read ↗

AQP1 differentially orchestrates endothelial cell senescenceSemantic proximity Read ↗

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular AgingSemantic proximity Read ↗

miR‐181b regulates vascular endothelial aging by modulating an MAP3K3 signaling pathwaySemantic proximity Read ↗

Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.