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CDC42 deficiency leads to endometrial stromal cell senescence in recurrent implantation failure

14 Oct 2024

Abstract excerpt

STUDY QUESTION: Does the downregulation of cell division cycle 42 (CDC42) protein in endometrial stroma lead to endometrial senescence in patients with recurrent implantation failure (RIF), and what is the potential mechanism? SUMMARY ANSWER: CDC42 deficiency causes endometrial stromal senescence and decidualization defects, impairing uterine receptivity of RIF patients, via activation of Wnt signaling pathway....

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PMID: 39487595
DOI: 10.1093/humrep/deae246

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