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Article

MicroRNA-216a induces endothelial senescence and inflammation via Smad3/IκBα pathway.

Journal of cellular and molecular medicine - 1 May 2018

Yang Shujun, Mi Xuenan, Chen Yu, Feng Congrui, Hou Zhihui, Hui Rutai, Zhang Weili

Abstract excerpt

Vascular endothelial senescence contributes to atherosclerosis and coronary artery disease (CAD), but the mechanisms are yet to be clarified. We identified that microRNA-216a (miR-216a) significantly increased in senescent endothelial cells. The replicative senescence model of human umbilical vein endothelial cells (HUVECs) was established to explore the role of miR-216a in endothelial ageing and dysfunction....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29512862
DOI: 10.1111/jcmm.13567
PMCID: PMC5908109

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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