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Article

Adaptation in bacterial CRISPR-Cas immunity can be driven by defective phages.

Nature communications - 24 Jul 2014

Hynes Alexander P, Villion Manuela, Moineau Sylvain

Abstract excerpt

Clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated cas genes serve as a prokaryotic 'adaptive' immune system, protecting against foreign DNA elements such as bacteriophages. CRISPR-Cas systems function by incorporating short DNA 'spacers', homologous to invading DNA sequences, into a CRISPR array (adaptation). The array is then transcribed and matured into RNA molecules...

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Identifiers

PMID: 25056268
DOI: 10.1038/ncomms5399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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