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Article

Physical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system.

Physical biology - 1 Apr 2013

Han Pu, Niestemski Liang Ren, Barrick Jeffrey E, Deem Michael W

Abstract excerpt

Bacteria and archaea have evolved an adaptive, heritable immune system that recognizes and protects against viruses or plasmids. This system, known as the CRISPR-Cas system, allows the host to recognize and incorporate short foreign DNA or RNA sequences, called 'spacers' into its CRISPR system. Spacers in the CRISPR system provide a record of the history of bacteria and phage coevolution. We use a physical model...

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Identifiers

PMID: 23492852
DOI: 10.1088/1478-3975/10/2/025004
PMCID: PMC3652287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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