Article
CRISPR/Cas, the immune system of bacteria and archaea.
Science (New York, N.Y.) - 8 Jan 2010
Horvath Philippe, Barrangou Rodolphe
Abstract excerpt
Microbes rely on diverse defense mechanisms that allow them to withstand viral predation and exposure to invading nucleic acid. In many Bacteria and most Archaea, clustered regularly interspaced short palindromic repeats (CRISPR) form peculiar genetic loci, which provide acquired immunity against viruses and plasmids by targeting nucleic acid in a sequence-specific manner. These hypervariable loci take up genetic...
Topics
- Archaea
- Archaeal Proteins
- Bacteria
- Bacterial Proteins
- Bacteriophages
- Base Sequence
- Conserved Sequence
- Gene Transfer, Horizontal
- Genes, Archaeal
- Genes, Bacterial
- Genetic Loci
- Genome, Archaeal