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Article

Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response.

Molecular cell - 5 Jan 2017

Heler Robert, Wright Addison V, Vucelja Marija, Bikard David, Doudna Jennifer A, Marraffini Luciano A

Abstract excerpt

CRISPR loci and their associated (Cas) proteins encode a prokaryotic immune system that protects against viruses and plasmids. Upon infection, a low fraction of cells acquire short DNA sequences from the invader. These sequences (spacers) are integrated in between the repeats of the CRISPR locus and immunize the host against the matching invader. Spacers specify the targets of the CRISPR immune response through...

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Source

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Identifiers

PMID: 28017588
DOI: 10.1016/j.molcel.2016.11.031
PMCID: PMC5218886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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