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Article

CRISPR-Cas systems exploit viral DNA injection to establish and maintain adaptive immunity.

Nature - 6 Apr 2017

Modell Joshua W, Jiang Wenyan, Marraffini Luciano A

Abstract excerpt

Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems provide protection against viral and plasmid infection by capturing short DNA sequences from these invaders and integrating them into the CRISPR locus of the prokaryotic host. These sequences, known as spacers, are transcribed into short CRISPR RNA guides that specify the cleavage site of Cas nucleases in the genome of the invader. It...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28355179
DOI: 10.1038/nature21719
PMCID: PMC5540373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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