Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bacteriostatic antibiotics promote CRISPR-Cas adaptive immunity by enabling increased spacer acquisition.

Cell host & microbe - 12 Jan 2022

Dimitriu Tatiana, Kurilovich Elena, Łapińska Urszula, Severinov Konstantin, Pagliara Stefano, Szczelkun Mark D, Westra Edze R

Abstract excerpt

Phages impose strong selection on bacteria to evolve resistance against viral predation. Bacteria can rapidly evolve phage resistance via receptor mutation or using their CRISPR-Cas adaptive immune systems. Acquisition of CRISPR immunity relies on the insertion of a phage-derived sequence into CRISPR arrays in the bacterial genome. Using Pseudomonas aeruginosa and its phage DMS3vir as a model, we demonstrate that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptive Immunity
Share to Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bacteria

Share to Bacteriophages

Share to CRISPR-Cas Systems

Share to Genome, Bacterial

Share to Mutation

Share to Pseudomonas aeruginosa

Source

Identifiers

PMID: 34932986
DOI: 10.1016/j.chom.2021.11.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bacteriostatic antibiotics promote CRISPR-Cas adaptive immunity by enabling increased spacer acquisition.PMID 34932986Read ↗

Bacteriostatic antibiotics promote the evolution of CRISPR-Cas immunitySemantic proximity Read ↗

CRISPR-Cas in Pseudomonas aeruginosa provides transient population-level immunity against high phage exposures.Semantic proximity Read ↗

Bacterial biodiversity drives the evolution of CRISPR-based phage resistance in <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

The effect of phage genetic diversity on bacterial resistance evolution.Semantic proximity Read ↗

CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogensSemantic proximity Read ↗

Adaptation in bacterial CRISPR-Cas immunity can be driven by defective phages.Semantic proximity Read ↗

Eco-evolutionary feedbacks shape the evolution of constitutive and inducible defencesSemantic proximity Read ↗

Phage-mediated resolution of genetic conflict alters the evolutionary trajectory of <i>Pseudomonas aeruginosa</i> lysogensSemantic proximity Read ↗

CRISPR immunity drives rapid phage genome evolution in Streptococcus thermophilus.Semantic proximity Read ↗

CRISPR/Cas, the immune system of bacteria and archaea.Semantic proximity Read ↗

Transient eco-evolutionary dynamics early in a phage epidemic have strong and lasting impact on the long-term evolution of bacterial defences.Semantic proximity Read ↗

The population and evolutionary dynamics of phage and bacteria with CRISPR-mediated immunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.