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Article

Macrophages are recruited to hypoxic tumor areas and acquire a pro-angiogenic M2-polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin.

Oncotarget - 30 Jul 2014

Tripathi Chakrapani, Tewari Brij Nath, Kanchan Ranjana Kumari, Baghel Khemraj Singh, Nautiyal Naveen, Shrivastava Richa, Kaur Harbeer, Bhatt Madan Lal Bramha, Bhadauria Smrati

Abstract excerpt

TAMs, a unique and distinct M2-skewed myeloid population of tumor stroma, exhibiting pro-tumor functions is fast emerging as a potential target for anti-cancer immunotherapy. Macrophage-recruitment and M2-polarization represent key TAMs-related phenomenon that are amenable to therapeutic intervention. However successful translation of these approaches into effective therapeutic regimen requires better...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25051364
DOI: 10.18632/oncotarget.2110
PMCID: PMC4170629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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