Article

Inhibition of STAT3 by 2-Methoxyestradiol suppresses M2 polarization and protumoral functions of macrophages in breast cancer

2023-09-19

Abstract excerpt

<title>Abstract</title> <p>Background Breast cancer metastasis remains the leading cause of cancer-related deaths in women worldwide. Infiltration of tumor-associated macrophages (TAMs) in the tumor stroma is known to be correlated with reduced overall survival, and inhibitors of TAMs are sought after for reprogramming the tumor microenvironment. 2-Methoxyestradiol (2ME2), a potent anticancer and antiangiogenic...

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Literature Corpus work: d4975387-348b-5eeb-9784-4d3b21516aa8
DOI: 10.21203/rs.3.rs-3237364/v1

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