Article

TREM2 blockade reprograms HER2 CAR macrophages toward inflammatory phagocytes in breast cancer models

2026-06-05

Abstract excerpt

<title>Abstract</title> <p>Tumor-associated macrophages (TAMs) are key regulators of the breast tumor microenvironment and often display immunosuppressive functions that limit cellular immunotherapy efficacy. Triggering receptor expressed on myeloid cells 2 (TREM2) has emerged as a critical modulator of myeloid cell activity and a potential target to enhance the anti-tumor activity of engineered macrophages. Here...

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Literature Corpus work: 97ce9fa2-3789-519f-b251-c0086eb569ca
DOI: 10.21203/rs.3.rs-9679135/v1

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