Exosomes derived from rapamycin-treated 4T1 breast cancer cells induced polarization of macrophages to M1 phenotype.

doi:10.1002/bab.2473

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Exosomes derived from rapamycin-treated 4T1 breast cancer cells induced polarization of macrophages to M1 phenotype.

Biotechnology and applied biochemistry - 1 Oct 2023

Ghalavand Majdedin, Moradi-Chaleshtori Maryam, Dorostkar Ruhollah, Mohammadi-Yeganeh Samira, Hashemi Seyed Mahmoud

Abstract excerpt

M2 macrophages are the most prevalent type in the tumor microenvironment and their polarization to M1 type can be used as a potential cancer immunotherapy. Here, we investigated the role of tumor microenvironment and particularly purified exosomes in M2 to M1 macrophage polarization. Rapamycin treatment on triple-negative breast cancer cells (TNBC) was performed. Tumor cells-derived exosomes (called texosomes)...

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