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Article

Tumor-Associated Macrophage Subsets: Shaping Polarization and Targeting.

International journal of molecular sciences - 19 Apr 2023

Zhang Qindong, Sioud Mouldy

Abstract excerpt

The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the most abundant cell population and are present at all stages of tumor progression. They undergo M1/M2 polarization in response to signals derived from TME. M1 macrophages suppress tumor growth, while their M2 counterparts exert...

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Identifiers

PMID: 37108657
DOI: 10.3390/ijms24087493
PMCID: PMC10138703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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