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Article

Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.

PloS one - 1 Jan 2016

Vallerand David, Massonnet Gérald, Kébir Fatima, Gentien David, Maciorowski Zofia, De la Grange Pierre, Sigal-Zafrani Brigitte, Richardson Marion, Humbert Sandrine, Thuleau Aurélie, Assayag Franck, de Plater Ludmilla, Nicolas André, Scholl Suzy, Marangoni Elisabetta, Weigand Stefan, Roman-Roman Sergio, Savina Ariel, Decaudin Didier

Abstract excerpt

Drug discovery efforts have focused on the tumor microenvironment in recent years. However, few studies have characterized the stroma component in patient-derived xenografts (PDXs) and genetically engineered mouse models (GEMs). In this study, we characterized the stroma in various models of breast cancer tumors in mice. We performed transcriptomic and flow cytometry analyses on murine populations for a series of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27388901
DOI: 10.1371/journal.pone.0157670
PMCID: PMC4936680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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