Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma models

5 Jun 2015

Abstract excerpt

Hypoxia is a common feature of solid tumors, particularly in glioblastoma (GBM), and known to be a poor prognosis factor in GBM patients. The growth of GBM is also associated with a marked inflammation partially characterized by an accumulation of macrophage (MΦ) of the M2 phenotype. However, the transition between M1 MΦ (antitumoral) and M2 MΦ (protumoral) phenotypes is a dynamic process. We made the assumption...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Immune cells in cancer
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26942063
DOI: 10.1080/2162402x.2015.1056442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma modelsPMID 26942063Read ↗

Chemoradiation-Altered Micromilieu of Glioblastoma Cells Particularly Impacts M1-Like Macrophage ActivationSemantic proximity Read ↗

Tumor-Associated Macrophages and Their Functional Transformation in the Hypoxic Tumor MicroenvironmentSemantic proximity Read ↗

Xenoline-polarized macrophages as a physiologically relevant in vitro model of tumor- associated macrophages in glioblastomaSemantic proximity Read ↗

Hypoxia-induced polypoid giant cancer cells in glioma promote the transformation of tumor-associated macrophages to a tumor-supportive phenotype.Semantic proximity Read ↗

Spatial patterning and immunosuppression of glioblastoma immune contexture in hypoxic nichesSemantic proximity Read ↗

Dealing with Macrophage Plasticity to Address Therapeutic Challenges in Head and Neck Cancers.Semantic proximity Read ↗

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1Semantic proximity Read ↗

Macrophages are recruited to hypoxic tumor areas and acquire a pro-angiogenic M2-polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin.Semantic proximity Read ↗

Xenoline-polarized macrophages as an alternative in vitro model of tumor-associated macrophages in glioblastomaSemantic proximity Read ↗

Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas.Semantic proximity Read ↗

IL-10 secreted by M2 macrophage promoted tumorigenesis through interaction with JAK2 in gliomaSemantic proximity Read ↗

Microglia-glioma cross-talk: a two way approach to new strategies against glioma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.