Article
[Influencing Factors and Significance of Tumor-associated Macrophage Polarization in Tumor Microenvironment].
Zhongguo fei ai za zhi = Chinese journal of lung cancer - 20 Mar 2023
Ge Wenke, Wu Weibing
Abstract excerpt
Tumor-associated macrophages (TAMs), characterized by high plasticity, are the most abundant immune cells in the tumor microenvironment (TME). TAMs are recruited to tumor region in response to various TME components such as cytokines, chemokines as well as exosomes. Subsequently, these environmental cues induce a certain polarization state of TAMs, ranging from anti-tumor states (M1-like) to pro-tumor states...
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