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Tumor associated macrophages and neutrophils in tumor progression

12 Oct 2012

Abstract excerpt

Tumor-associated macrophages (TAMs) are a key component of the tumor microenvironment and orchestrate various aspects of cancer. Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In response to distinct signals macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a spectrum of activation states. Metabolic adaptation is a...

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PMID: 23065796
DOI: 10.1002/jcp.24260

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