Article
Association of functional polymorphism at the miR-502-binding site in the 3' untranslated region of the SETD8 gene with risk of childhood acute lymphoblastic leukemia, a preliminary report.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2014
Hashemi Mohammad, Sheybani-Nasab Maryam, Naderi Majid, Roodbari Fatemeh, Taheri Mohsen
Abstract excerpt
MicroRNAs (miRNAs), a class of non-coding RNAs, bind to the 3' untranslated regions (UTRs) of mRNAs, where they interfere with translation of genes and are implicated in the pathogenesis of diverse diseases. In the present study, we evaluate the impact of rs16917496 polymorphism within the miR-502 miRNA seed region at the 3'UTR of SEDT8 on childhood acute lymphoblastic leukemia (ALL). This case-control study was...
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