Genetic variation in a microRNA-502 minding site in SET8 gene confers clinical outcome of non-small cell lung cancer in a Chinese population.

doi:10.1371/journal.pone.0077024

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Article

Genetic variation in a microRNA-502 minding site in SET8 gene confers clinical outcome of non-small cell lung cancer in a Chinese population.

PloS one - 1 Jan 2013

Xu Jiali, Yin Zhiqiang, Gao Wen, Liu Lingxiang, Yin Yongmei, Liu Ping, Shu Yongqian

Abstract excerpt

BACKGROUND: Genetic variants may influence microRNA-target interaction through modulate their binding affinity, creating or destroying miRNA-binding sites. SET8, a member of the SET domain-containing methyltransferase, has been implicated in a variety array of biological processes. METHODS: Using Taqman assay, we genotyped a polymorphism rs16917496 T>C within the miR-502 binding site in the 3'-untranslated region...

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PMID: 24146953
DOI: 10.1371/journal.pone.0077024
PMCID: PMC3795636

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