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Article

A polymorphism at the miR-502 binding site in the 3'-untranslated region of the histone methyltransferase SET8 is associated with hepatocellular carcinoma outcome.

International journal of cancer - 15 Sept 2012

Guo Zhanjun, Wu Chensi, Wang Xiaoling, Wang Cuiju, Zhang Ruixing, Shan Baoen

Abstract excerpt

MicroRNAs (miRNAs) can bind to the 3'-untranslated regions (UTRs) of messenger RNAs, where they interfere with translation and thereby regulate cell differentiation, apoptosis and tumorigenesis. Genetic polymorphisms in the 3'-UTRs targeted by miRNAs alter the strength of miRNA binding in a manner that affects the behavior of individual miRNAs. The histone methyltransferase SET8 has been reported to methylate...

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PMID: 22095217
DOI: 10.1002/ijc.27352

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A polymorphism at the miR-502 binding site in the 3'-untranslated region of the histone methyltransferase SET8 is associated with hepatocellular carcinoma outcome.PMID 22095217Read ↗

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