Article
Noncoding RNA-related polymorphisms in pediatric acute lymphoblastic leukemia susceptibility.
Pediatric research - 1 Jun 2014
Gutierrez-Camino Angela, Lopez-Lopez Elixabet, Martin-Guerrero Idoia, Piñan Maria A, Garcia-Miguel Purificacion, Sanchez-Toledo Jose, Carbone Bañeres Ana, Uriz Javier, Navajas Aurora, Garcia-Orad Africa
Abstract excerpt
BACKGROUND: Evidence for an inherited genetic risk for pediatric acute lymphoblastic leukemia has been provided in several studies. Most of them focused on coding regions. However, those regions represent only 1.5% of the entire genome. In acute lymphoblastic leukemia (ALL), it has been suggested that the expression of microRNAs (miRNAs) is dysregulated, which suggests that they may have a role in ALL risk....
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