Functional polymorphism at the miR-502-binding site in the 3' untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population.

doi:10.1016/j.gene.2017.05.060

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Article

Functional polymorphism at the miR-502-binding site in the 3' untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population.

Gene - 30 Aug 2017

Narouie Behzad, Ziaee Seyed Amir Mohsen, Basiri Abbas, Hashemi Mohammad

Abstract excerpt

MicroRNAs (miRNAs), a class of non-coding RNAs, bind to the 3' untranslated regions (3'-UTRs) of target mRNAs and regulate gene expression. Genetic variations in miRNA binding domains influence the susceptibility to several diseases such as cancer. Several studies investigated the impact of single-nucleotide polymorphism (SNP) rs16917496 T>C within the 3'-UTR of SETD8 on cancer susceptibility, but the results...

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PMID: 28578017
DOI: 10.1016/j.gene.2017.05.060

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