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Article

Molecular control of arsenite-induced apoptosis in Caenorhabditis elegans: roles of insulin-like growth factor-1 signaling pathway.

Chemosphere - 1 Oct 2014

Wang Shunchang, Teng Xiaoxue, Wang Yun, Yu Han-Qing, Luo Xun, Xu An, Wu Lijun

Abstract excerpt

Apoptosis is one of the main cellular processes in responses to arsenic, the well known environmental carcinogen. By using the nematode Caenorhabditis elegans as an in vivo model, we found that insulin-like growth factor-1 networks and their target protein DAF-16/FOXO, known as key regulators of energy metabolism and growth, played important roles in arsenite-induced apoptosis. Inactivation of DAF-2, AGE-1 and...

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PMID: 25048913
DOI: 10.1016/j.chemosphere.2014.04.021

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PDK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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