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Article

Role of Caenorhabditis elegans AKT-1/2 and SGK-1 in Manganese Toxicity.

Neurotoxicity research - 1 Oct 2018

Peres Tanara V, Arantes Leticia P, Miah Mahfuzur R, Bornhorst Julia, Schwerdtle Tanja, Bowman Aaron B, Leal Rodrigo B, Aschner Michael

Abstract excerpt

Excessive levels of the essential metal manganese (Mn) may cause a syndrome similar to Parkinson's disease. The model organism Caenorhabditis elegans mimics some of Mn effects in mammals, including dopaminergic neurodegeneration, oxidative stress, and increased levels of AKT. The evolutionarily conserved insulin/insulin-like growth factor-1 signaling pathway (IIS) modulates worm longevity, metabolism, and...

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Identifiers

PMID: 29882004
DOI: 10.1007/s12640-018-9915-1
PMCID: PMC6286235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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