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Article

Cadmium-induced germline apoptosis in Caenorhabditis elegans: the roles of HUS1, p53, and MAPK signaling pathways.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Apr 2008

Wang Shunchang, Tang Minli, Pei Bei, Xiao Xiang, Wang Jun, Hang Haiying, Wu Lijun

Abstract excerpt

The transition metal cadmium (Cd) has been shown to induce apoptosis in a variety of cell lines and tissues. Caspase activation of the tumor suppressor gene p53 and mitogen-activated protein kinase (MAPK) signaling cascades have been reported to be involved in Cd-induced apoptosis. However, the underlying pathways of Cd-induced apoptosis have not been clearly elucidated in the in vivo systems, primarily for the...

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Identifiers

PMID: 17728284
DOI: 10.1093/toxsci/kfm220

Genes

HUS1
ABL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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