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Cadmium exposure induces multigenerational inheritance of germ cell apoptosis and fertility suppression in Caenorhabditis elegans

14 Aug 2024

Abstract excerpt

• Cd exposure triggers epigenetic changes resulting in a transgenerational increase in germ cell apoptosis and an intergenerational decrease in fertility in C. elegans . • The transgenerational epigenetic inheritance effect induced by Cd exposure depends on the transcription factors DAF-16/FOXO and SKN-1/Nrf2. • H3K4me3 modifications act as epigenetic marks in the Cd exposure-induced transgenerational epigenetic...

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PMID: 39159515
DOI: 10.1016/j.envint.2024.108952

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