Article

Sanguinarine activates ATM/ATR-mediated CHK-1 signaling to drive p53-dependent apoptosis in the <i>C. elegans</i> germline

2026-01-27

Abstract excerpt

Sanguinarine (SNG) is a natural component belonging to the benzophenanthridine alkaloids. In recent years, due to its remarkable biological activities, it has gained wide interest in the pharmaceutical industry. Various studies have reported its potential as a therapeutic agent in treating chronic human diseases such as cancer. SNG is widely reported to cause programmed cell death in various cancer cell lines. The...

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Literature Corpus work: 9887643e-a4bd-52ac-b6b3-592e23c995da
DOI: 10.64898/2026.01.26.701699

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