Article
Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan.
Aging cell - 1 Aug 2007
Kim Yongsoon, Sun Hong
Abstract excerpt
Genetic studies in many organisms suggest that an increased animal lifespan phenotype is often accompanied by enhanced resistance toward reactive oxygen species (ROS). In Caenorhabditis elegans, mutations in daf-2, which encode an insulin/insulin-like growth factor 1 receptor-like molecule, lead to an extended animal lifespan and increased resistance to ROS. We have optimized an assay to monitor ROS resistance in...
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